Hyaluronidase spread and the effect of salicylates in rheumatic fever.
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چکیده
منابع مشابه
The influence in vitro of deoxycorticosterone on glycogen formation in muscle.
In view of the evidence which has been presented that hyaluronidase is not inhibited by salicylates in therapeutic concentrations, it would seem that Guerra's explanation of the anti-rheumatic action of these drugs in terms of hyaluronidase inhibition must be abandoned. The question naturally arises as to whether or no their apparent anti-histamine action can be invoked in this connexion, as we...
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This study* was undertaken to ascertain the effect of salicylate on the spreading activity of testicular extract (T.E.) in the human skin, and its relationship to rheumatic disease. Introduction Hyaluronidase.-It was shown by Duran-Reynals (1928) and McClean (1930) that testicular extract would enhance the infection by vaccinia virus. DuranReynals (Hoffman and Duran-Reynals, 1930) further noted...
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Hyaluronidase has been shown to increase the rate of spread of intradermally injected solutions in animals (Chain and Duthie, 1939, 1940) and the whole subject of spreading factors was reviewed by Duran-Reynals (1942). Holborow and Keech (1951) studied the effects of hyaluronidase in accelerating the rate of spread of a solution of haemoglobin injected intradermally in normal human subjects and...
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A trial was conducted using sequential analysis by pairs to compare the efficacy of corticosteroids and salicylates in the treatment of acute rheumatic carditis. The results show a significantly favourable effect of steroid treatment both in clinical response and in reduction of the erythrocyte sedimentation rate. In addition, patients receiving steroids usually had a shorter hospital stay. The...
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عنوان ژورنال:
- Annals of the rheumatic diseases
دوره 10 4 شماره
صفحات -
تاریخ انتشار 1951